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Insights into the allosteric regulation of Syk association with receptor ITAM, a multi-state equilibrium

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Phys. Chem. Chem. Phys., 2015, Advance Article
DOI: 10.1039/C5CP05417F, Paper
Chao Feng, Carol Beth Post
Syk high-affinity association with receptor ITAM is regulated by a phosphorylation-dependent allosteric mechanism. NMR titration-curve/line-shape analyses determined phosphorylation increases the energetic barrier for, but does not prevent, isomerization.
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