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How fluorescent labelling alters the solution behaviour of proteins

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Phys. Chem. Chem. Phys., 2015, Advance Article
DOI: 10.1039/C5CP04463D, Paper
M. K. Quinn, N. Gnan, S. James, A. Ninarello, F. Sciortino, E. Zaccarelli, J. J. McManus
The impact of adding a fluorescent dye to a protein is examined using protein phase diagrams and numerical simulations. The addition of the dye is the equivalent of adding a large attractive patch to the surface of the protein, which results in significant changes to the protein solution behaviour.
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