The structural analysis of the pro-oxidant copper-binding site of denatured apo-H43R SOD1 and the elucidation of the origin of acquisition of the pro-oxidant activity

Phys. Chem. Chem. Phys., 2016, Accepted Manuscript
DOI: 10.1039/C5CP07729J, Paper

Nobuhiro Fujimaki, Takashi Miura, Takakazu Nakabayashi
The pathogenesis of amyotrophic lateral sclerosis (ALS) is associated with mutations of Cu,Zn-superoxide dismutase (SOD1), which is a representative antioxidant enzyme. A previous study showed that the denatured apo-form of...
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